Promethazine Promethazine can be a phenothiazine by-product, which differs structurally from your antipsychotic phenothiazines because of the existence of the branched aspect chain and no ring substitution.

For those who pass up a dose, consider it the moment you could. If it is nearly time for your next dose, take only that dose. Usually do not take double or extra doses.

The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Alternative may perhaps increase the frequency of seizures in people with seizure Problems, and should boost the threat of seizures developing in other medical configurations connected with seizures.

The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate.

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An increased risk of unique malformations with codeine exposure such as respiratory malformations, spina bifida and congenital heart defects were being described in certain scientific studies.

In animal copy experiments, codeine administered by the oral route to pregnant rats in the period of organogenesis elevated resorptions and lessened fetal weights at a dose somewhere around twenty five occasions the utmost advised human dose (MRHD) inside the presence of maternal toxicity (see Details).

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Labor or Shipping Opioids cross the placenta and could develop respiratory melancholy and psycho-physiologic consequences in neonates. An opioid antagonist, like naloxone, needs to be readily available for reversal of opioid-induced respiratory depression from Promethazine codeine syrup the neonate.

Postmarketing instances of respiratory despair, which include fatalities have already been claimed with utilization of promethazine in pediatric people.

Carefully measure the dose using a Exclusive measuring system/spoon. Usually do not make use of a domestic spoon as you may not get the right dose.

Treatment method of Overdose Treatment of overdosage is pushed by the general clinical presentation, and includes discontinuation of Promethazine HCl and Codeine Phosphate Oral Solution along with establishment of suitable therapy. Give Principal notice towards the reestablishment of enough respiratory Trade by way of provision of a patent and protected airway along with the establishment of assisted or managed air flow.

Promethazine and codeine may well lead to marked drowsiness or may well impair the mental and/or Actual physical talents demanded for your efficiency of potentially hazardous duties, which include driving a car or truck or operating machinery.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals under six several years of age, mainly because The mix may perhaps cause fatal respiratory melancholy Within this age inhabitants. It is vital that promethazine with codeine syrup is calculated using an exact measuring device (see PRECAUTIONS-Information and facts For Patients).